GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs17761864 | 1 | rs1885986 | chr17:2203175 | SRR | chr17:2207248-2228553:+ | -0.54 | -5.48 | 3.47E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs10461617 | 1 | rs190414 | chr5:56116772 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs1875620 | 1 | rs1910272 | chr9:91559042 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1577917 | 1 | rs1911552 | chr6:86638024 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs1911553 | chr6:86630892 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs10935120 | 1 | rs1917130 | chr3:134313773 | ANAPC13 | chr3:134196547-134204865:- | -0.57 | -7.63 | 1.8E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs1917130 | chr3:134313773 | CEP63 | chr3:134204575-134293852:+ | -0.42 | -6.1 | 2.28E-8 | Height |
| THYM | cis | rs1930961 | 1 | rs1930961 | chr22:25875265 | CRYBB2 | chr22:25615612-25627836:+ | 1.12 | 7.51 | 3.14E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs1577917 | 1 | rs1962716 | chr6:86648436 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.96 | 4.28E-10 | Response to antipsychotic treatment |
| THYM | cis | rs7210837 | 1 | rs1964555 | chr17:16763555 | TRPV2 | chr17:16318888-16340315:+ | 0.23 | 4.14 | 7.43E-5 | Response to platinum-based chemotherapy (cisplatin) |
| THYM | cis | rs2243480 | 1 | rs1964692 | chr7:65454183 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs1451375 | 1 | rs1966839 | chr7:50627101 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.66 | 1.03E-5 | Malaria |
| THYM | cis | rs7849270 | 1 | rs1977447 | chr9:131868196 | CRAT | chr9:131857075-131873070:- | -0.47 | -5.46 | 3.85E-7 | Blood metabolite ratios |
| THYM | cis | rs41266839 | 1 | rs1979 | chr6:26377591 | BTN3A2 | chr6:26365398-26378546:+ | -0.74 | -5.26 | 8.76E-7 | Schizophrenia |
| THYM | cis | rs2243480 | 1 | rs1979823 | chr7:65704613 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |